Metrics details. Accurate estimates of the burden of antimicrobial resistance AMR are needed to establish the magnitude of this global threat in terms of both health and cost, and to paramaterise cost-effectiveness evaluations of interventions aiming to tackle the problem. This review aimed to establish the alternative methodologies used in estimating AMR burden in order to appraise the current evidence base. A study quality score from zero to one was derived using Newcastle-Ottawa and Philips checklists.
Systematic review of guidelines in estimating social costs on drugs
Costs of Illness of Spinal Muscular Atrophy: A Systematic Review | SpringerLink
Introduction: A systematic literature review was conducted to review and summarize the economic impact of non-medical switching NMS from biologic originators to their biosimilars i. Methods: English publications reporting healthcare resource utilization HRU or costs associated with biosimilar NMS were searched in PubMed and EMBASE over the past 10 years and from selected scientific conferences over the past 3 years, along with gray literature for all biologics with an approved biosimilar e. Results: A total of publications were retrieved, where 54 studies met the selection criteria. Among the studies that the estimated cost impact associated with NMS, 33 reported drug costs reduction, 12 reported healthcare costs post-NMS without a detailed breakdown, and 5 reported NMS setup and managing costs. However, variation across studies was substantial because of heterogeneity in study designs and assumptions e. Conclusion: Real-world studies reporting the economic impact of biosimilar NMS separately from drug costs are emerging, and those that reported such results found increased HRU in patients with biosimilar NMS.
Estimating the burden of antimicrobial resistance: a systematic literature review
Metrics details. Economic evaluations help decision-makers faced with tough decisions on how to allocate resources. Systematic reviews of economic evaluations are useful as they allow readers to assess whether interventions have been demonstrated to be cost effective, the uncertainty in the evidence base, and key limitations or gaps in the evidence base. The synthesis of systematic reviews of economic evaluations commonly takes a narrative approach whereas a meta-analysis is common step for reviews of clinical evidence e.
Heart failure presents a growing clinical and economic burden in the USA. Robust cost data on the burden of illness are critical to inform economic evaluations of new therapeutic interventions. This systematic literature review of heart failure-related costs in the USA aimed to assess the quality of the published evidence and provide a narrative synthesis of current data.