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Literature review on congenital hypothyroidism

How to cite: Al jabri, A. Preprints , Al jabri, A. Preprints , Copy. Al jabri, A. Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Thyroid dysfunction in children with Down syndrome: a literature review

Though the motor and cognitive development of patients with congenital hypothyroidism CH has been well studied, the emotional and social aspects of growing up with CH are deserving of further exploration, according to a study. The researchers relied on data gathered through questionnaires filled out by children with CH and their parents. The researchers then used a number of statistical models to compare the differences between the HRQoL scores of the children with CH and the general population. The results of the study showed that the children with CH had lower average HRQoL with regards to their motor skills, cognitive and social functioning, autonomy, and positive emotions. The researchers conclude that their findings demonstrate the prevalence of impaired HRQoL and self-worth among children with CH. The researchers say that this highlights the need for doctors to pay close attention to the emotional aspects of CH and provide patients with appropriate care. Can Patients Find You?
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Genetics of primary congenital hypothyroidism—a review

Congenital hypothyroidism CH is one of the most common preventable and treatable cause of intellectual impairment in children. Among known etiologies dysgenesis due to abnormal anatomical development and dyshormonogenesis as a result of deranged physiological functioning of fetal thyroid gland. While review of literature report thyroid dysgenesis as the most common etiology of CH currently focus is on iodine status adequacy in women before and during pregnancy and after delivery and lactation. Worldwide reports of previously iodine sufficient countries declared presently as iodine insufficient and recent publications of several Indian states consuming lesser amounts of iodized salt seem to indicate that iodine related pathophysiological factors are emerging as predominant etiologies of CH. The most vulnerable pregnant women and newborns are prone to be affected with iodine imbalances leading to pregnancy and perinatal related complications.
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